Evaluation of Antiproliferative Potential of Cerium Oxide Nanoparticles on HeLa Human Cervical Tumor Cell

Zorița Diaconeasa, Lucian Barbu Tudoran, Cristina Coman, Loredana Leopold, Amalia Mesaroș, Oana Pop, Dumitrița Rugină, Carmen Socaciu

Abstract


Cerium oxide nanoparticles (CeO2 nanoparticles) as nanomaterials have promising biomedical applications. In this paper, the cytotoxicity induced by CONPs human cervical tumor cells was investigated. Cerium oxide nanoparticles were synthesized using the precipitation method. The nanoparticles were found to inhibit the proliferation of HeLa human cervical tumor cells in a dose dependent manner but did not showed to be cytotoxic as analyzed by MTT assay. The administrated treatment decreased the HeLa cell viability cells from 100% to 65% at the dose of 100 μg/mL.

Keywords


nanoparticles, cerium, cervical cancer, MTT

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References


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DOI: http://dx.doi.org/10.15835/buasvmcn-fst:11138

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