Evaluation of Antiproliferative Potential of Cerium Oxide Nanoparticles on HeLa Human Cervical Tumor Cell

  • Zorița Diaconeasa Faculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372, Cluj-Napoca
  • Lucian Barbu Tudoran Faculty of Biology & Geology, Babes-Bolyai University, Clinicilor 5-7, 400006 Cluj-Napoca
  • Cristina Coman Faculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372, Cluj-Napoca
  • Loredana Leopold Faculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372, Cluj-Napoca
  • Amalia Mesaroș Faculty of Materials Engineering and Environment, Technical University Cluj-Napoca, Bul. Muncii 103-105, 400641, Cluj-Napoca
  • Oana Pop Faculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372, Cluj-Napoca
  • Dumitrița Rugină Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372, Cluj-Napoca
  • Carmen Socaciu Faculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372, Cluj-Napoca
DOI: https://doi.org/10.15835/buasvmcn-fst:11138
Keywords: nanoparticles, cerium, cervical cancer, MTT

Abstract

Cerium oxide nanoparticles (CeO2 nanoparticles) as nanomaterials have promising biomedical applications. In this paper, the cytotoxicity induced by CONPs human cervical tumor cells was investigated. Cerium oxide nanoparticles were synthesized using the precipitation method. The nanoparticles were found to inhibit the proliferation of HeLa human cervical tumor cells in a dose dependent manner but did not showed to be cytotoxic as analyzed by MTT assay. The administrated treatment decreased the HeLa cell viability cells from 100% to 65% at the dose of 100 μg/mL.

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Published
2015-05-21
Issue
Vol. 72 No. 1 (2015): BULLETIN OF UNIVERSITY OF AGRICULTURAL SCIENCES AND VETERINARY MEDICINE CLUJ-NAPOCA. FOOD SCIENCE AND TECHNOLOGY
Section
Research Articles
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