MORUS NIGRA L. LEAVES – THERAPEUTIC PROPERTIES IN LIVER DISEASES AND RELATED DISORDERS

Maria Valentina SOCACI (IGNAT), Elena MUDURA, Teodora Emilia COLDEA, Liana SALANTA

Abstract


Over the last years Morus nigra L. raised an interest in various research fields. Several studies assessed their polyphenolic profile and mulberry leaves and fruits are currently used as ingredients in teas, beverages and functional products highlighting their antioxidant properties. This study focused on finding out how mulberry leaf extracts could impact liver diseases. Non-alcoholic steatohepatitis (NASH) is the leading cause of chronic liver disorders. The currently proposed pharmaco-therapies are studied for safety and efficacy therefore, alternative aids are needed. This work attempts to highlight the therapeutic properties of mulberry leaf extracts through a review of in vitro and in vivo studies. Current research on mulberry leaves extracts shows that their content of bioactive compounds can reduce palmitic acid-induced lipotoxicity, promote total cholesterol and bile acid excretion, enhance SOD expression, and improve insulin resistance. Morus nigra L. leaves present hepatoprotective, anti-inflammatory, antioxidant, hypolipidemic, and hypoglycemic activities. They are also shown as beneficial in the management of obesity, dyslipidemia, type 2 diabetes, NAFLD and NASH. Given the reported therapeutic benefits of mulberry leaf extracts in the management of liver diseases and related disorders and considering the urgency of providing alternative solutions to managing such diseases, mulberry leaves might be valuable ingredients in developing functional products in the management of liver disorders.


Keywords


mulberry leaves, functional products, liver disorders, Morus nigra L

Full Text:

PDF