ALMOND SEEDS AND BRAZIL NUTS - FOODS WITH ANTIOXIDANT POTENTIAL RECOMMENDED FOR PATIENTS WITH PHENYLKETONURIA

Alexandra Cornelia VLAD, Emanuel MUREȘAN, Denisa PÎNZARIU, Vanda BABALAU-FUSS, Oana Bogdana GREBLA, Ana Ioana POP, Ioana TALOS, Maria TOFANĂ

Abstract


Phenylketonuria (PKU) is an autosomal recessive genetic metabolic disease (both alleles are mutant) due to phenylalanine hydroxylase (PAH) deficiency. Enzyme deficiency causes excessive accumulation of phenylalanine in the bloodstream, affecting the central nervous system. Neuropsychiatric disorders and mental retardation can be prevented through an adequate diet, the main nutritional goal being the reduced intake of phenylalanine. Therapeutic intervention is sustained throughout life; it consists of a hygienic diet that aims to limit the intake of phenylalanine. Several studies have shown a decrease in antioxidant capacity in patients with PKU. Almonds (Prunus dulcis) are an important source of vitamin E (α-tocopherol), a fat-soluble vitamin with an antioxidant role. Brazil nuts (Bertolletia excelsa) are among the richest sources of selenium. The literature describes low selenium levels in patients with PKU. These functional foods could be used in the development of a supplement with antioxidant potential.

Keywords


phenylketonuria, antioxidant, functional.

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