Evaluation of Isoflurane and Sevoflurane Influence on Liver

Flavia Ruxanda, Viorel Miclaus, Vasile Rus, Adrian Gal, Cristian Rațiu, Liviu Oana


The specialty literature contains uneven data regarding the effect of inhaled anesthetics on transaminases’ values. Various studies show that the transaminases’ values range from a small increase up to a massive increase post-anesthesia. In the present study, we utilized 40 rats, divided in 8 groups (n=5). Animals from IsoM and SevoM groups (control) were not anesthetized. Rats from IsoI, Iso2, Iso3 groups were anesthetized with isoflurane, and the ones from Sevo1, Sevo2, Sevo3 groups with sevoflurane (3 times, with 2 days interval between administrations, and the exposure time was 2 hours long every time). After anesthesia, we harvested blood samples at different moments: immediately after the anesthesia (groups IsoM, SevoM, Iso1 and Sevo1), 6 hours post-anestesia (Iso2 and Sevo2) and 24 hours post-anesthesia (Iso3 and Sevo3) and determined the transaminases. Upon statistical analysis, the results indicated the fact that the two anesthetics taken into study did not significantly modify the ASAT values. Also, isoflurane din not significantly modify ALAT values. On the other hand, after sevofluran anesthesia, ALAT values increased very significantly 6 hours post-anesthesia and significantly 24 hours post-anesthesia. Enzymatic values ranged between normal limits or were slightly increased over the superior limit, which signifies that at the anesthetic dose and duration from our study, none of the tested anesthetics induce hepatic distress.


alanine aminotransferase, aspartate aminostransferase, isoflurane, sevoflurane

Full Text:


DOI: http://dx.doi.org/10.15835/buasvmcn-vm:11373

University of Agricultural Sciences and Veterinary Medicine
3-5 Manastur St., 400372 Cluj-Napoca
Tel: +40-264-596.384 | Fax: +40-264-593.792