Radiological Aspects of BRONJ after Dental Extractions in Ovariectomized Female Wistar Rats

Adela Cristina LAZĂR, Radu LĂCĂTUȘ, Robert PURDOIU, Lucia BEL, Orsolya SARPATAKI, Mariana PĂCURAR, Radu Septimiu CÂMPIAN


Experimental study in animal model - female Wistar rats – using two types of bisphosphonates (ibandronic acid and denosumab) for treating osteoporosis induced by ovariectomy, performing extractions in the maxillary central incisors and occurance of bisphosphonates related osteonecrosis of the jaw (BRONJ) after the dental extractions. The appearance of BRONJ in female Wistar rats which had undergone ovariectomy in advance and received two types of bisphosphonates and a comparison between 3 groups show that BRONJ it is first diagnosticated radiological, before it is first signs in oral cavity. Therefore, careful monitoring of patients undergoing bisphosphonate therapy is essential in the clear and accurate diagnosis of BRONJ. According to the experiment conducted by us, the administration of this class of bisphosphonates has antibacterial effects, decrease osteoclasts activity and thus decrease the bone resorption, but as a secondary main effect it induces BRONJ after performing routine dental surgeries.


bisphosphonates, BRONJ, dental extractions, lamina dura, ovariectomy.

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