Caralluma Acutangula Prevents Body Weight Gain in Rats Feed on Hyperlipidic Diet

Pare DRAMANE, Hilou ADAMA, Adrian POTÂRNICHE, Mabozou KPEMISSI, Orsolya SÁRPATAKI, Ouedraogo NOUFOU, Alexandra I. BLIDARU, Marian TAULESCU, Guenne SAMSON, Ioan MARCUS, Sanda ANDREI, Bogdan SEVASTRE

Abstract


Caralluma acutangula (Decne.) (CA) (Asclepiadaceae) is a medicinal plant traditionally used in Burkina Faso for the management of weight. The aim of this study was to evaluate the effect of extract of CA on body weight, food intake, blood biochemistry parameters on experimental obesity rat model. One group received CA 400 mg/kg b.w. per day and was fed on hyperlipidic diet (HD), while the control group received HD only for three weeks long. The phytochemical investigation of extract showed a high total phenolic content (36.21±1.36 mg GAE/100mg of extract) and total flavonoids (4.98 ±0.31 QE/100 mg of extract). In the end, CA-HD treated group had a body weight loss of 2%, compared to HD group who presented a body weight gain of 15%. The CA-HD treated group showed also a lower levels of plasma triglyceride (136.57±13.82 mg/dL) and glycemia (187.74±31.16 mg/dL) compared to HD (206.02±23.82 and respectively 230.96±79.07 mg/dL) (p<0.05). CA extract also showed a good anti-oxidant activity in vivo (effect on antioxydant enzyme (MDA, GPX, SOD) and in vitro (inhibition of DPPH radical, ferric ion reduction). This study showed that CA is a potential natural remedy for the control of body weight and alleviation of obesity related disease.

Keywords


phytotherapy; obesity; antioxidant activity

Full Text:

PDF


DOI: http://dx.doi.org/10.15835/buasvmcn-vm:006617


University of Agricultural Sciences and Veterinary Medicine
3-5 Manastur St., 400372 Cluj-Napoca
Romania
Tel: +40-264-596.384 | Fax: +40-264-593.792
biroupublicatii@usamvcluj.ro