ALUMINIUM SULPHATE IMPACT ON SOME MARKERS OF FEMALE REPRODUCTIVE SYSTEM PERFORMANCES (LITTER SIZE, SEX RATIO) AND OF PHYSICAL DEVELOPMENT (VAGINAL OPENING) IN RATS

Alexandra Trif, Eugenia Dumitrescu, F Muselin

Abstract


The study was carried out on 21 white Wistar adult female rats (exposed to 200, 400 and 1000 ppb Al) mated with white Wistar males (ratio 2 female/1 male) exposed to same aluminium levels to obtain F1 generation. There were evaluated in F1 (exposed in utero)number and sex of pups, sex ratio, markers of physical development in the context of data on sexual maturation (age and body weight at vaginal opening). The study pointed out significant decrease of litter size comparative to control group and inversely correlated to exposure level; modification of sex ration, increase of female pups number/one male pups comparative to C group, not evidently influenced by exposure level; significant delay of vaginal opening comparative to control group but not correlated to exposure level; decrease of body weight at vaginal opening comparative to control group, not correlated to exposure level.

Keywords


aluminium, rats, F1, litter size, sex, vaginal opening

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DOI: http://dx.doi.org/10.15835/buasvmcn-vm:65:2:1556


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