ANTICOAGULANT MECHANISMS IN SURGICAL PATIENTS

Brudaşcă Ioana, M. Cucuianu

Abstract


Protein C (PC) and its cofactor protein S (PS) are potent physiological anticoagulant mechanisms. As thrombotic events are known to be a major complication of the surgical procedures, we studied the behavior of these anticoagulant mechanisms in surgical patients. PC:Ag level was significantly decreased (63,3 ± 4,2, p< 0,001) in 29 critically - ill surgical patients when compared to 32 healthy control subjects. When compared to 10 controls subjects, PS:Ag was also significantly decreased (59,2 ± 4,96, p< 0,01) in 12 surgical patients in critical condition. These changes could be explained by the switch of the hepatic protein synthesis during the acute phase reaction developing in critically ill surgical patients towards the increased production of acute phase proteins, while reducing the secretion of PC and PS, cholinesterase and albumin. These observations emphasize the risk for thrombosis in postoperative states and stress the importance of a thorough investigation of hemostasis in surgical patients.

Keywords


anticoagulant mechanisms, protein C, protein S, surgical patients

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DOI: http://dx.doi.org/10.15835/buasvmcn-vm:64:1-2:2436




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