PLASMA BIOCHEMISTRY IN EXPERIMETAL ASBESTOSIS

B. Sevastre, Adela Joantă, Simona Gabor, C. Cătoi, A.I. Baba

Abstract


Asbestos are hydrated silicate fibres, responsible for wide range injuries like inflammation, fibrosis, even malignancy. The purpose of present paper was to reveal the plasma biochemical changes in rat experimental asbestosis. The experiment was carried out 240 days long, on Wistar rats, intraperitoneally injected once with aqueous asbestos suspension. Plasma samples were used in order to determine general metabolic status, inflammatory markers and oxidative stress. The values of uric acid, amylase, ALAT, ASAT, AP, triglycerides, cholesterol, urea, creatinin, glucose, bilirubin, total proteins, plasma ions (Ca2+, Mg2+, Fe3+, Na+, K+) revealed no notable changes. Increased values were found in immunoglobulin levels (IgM and IgG), C reactive protein and complement 3 fraction. Oxidative stress markers as ceruloplasmin malonildialdehyde and total hydrogen donor ability were also increased, but protein carbonyl revealed no significant differences. In conclusion, our findings revealed that asbestos fibers effects are far beyond the local proliferative lesions, but they induced an systemic inflammatory response. In blood, this response affects immune system compounds and induces a strong oxidative stress.

Keywords


sbestos, plasma, inflammation, oxidative stress

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DOI: http://dx.doi.org/10.15835/buasvmcn-vm:63:1-2:2451




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