CLINICAL, PARACLINICAL AND THERAPEUTIC EVALUATIONS OF ACETAMINOPHEN TOXICOSIS IN DOGS

N. A Oros, R. L. Fârcal, Anca Mărculescu, M. Cernea, G. A. Bâle

Abstract


Our retrospective study consisted in monitoring the clinical, paraclinical and therapeutically aspects in acetaminophen toxicosis in dogs. The study was realized on 11 cases (between 4 months and 8 years old dogs) represented by 8 males and 3 females. The animals were diagnosed with acetaminophen toxicosis in a private veterinary clinic. The diagnosis was established by anamnesis, clinical examination and biochemical tests from blood (creatinine, BUN, glucose, total bilirubin, alkaline phosphatasis and ALT). The main clinical signs of acetaminophen toxicosis were caused by hepatic-toxicity develop and were represented by vomiting, anorexia, icterus, colics and haemoglobinuria. The main changes of biochemical parameters were characterized by: hyperglycemia, increasing of total bilirubinemia and the increasing of AP and ALT activity. The neutralisation of metabolic acidosis and methaemoglobinemia can conduct to well recover of the animals, if these products are added to the acetylcysteine antidote

Keywords


acetaminophen toxicity, dogs, biochemical tests, acetylcysteine

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DOI: http://dx.doi.org/10.15835/buasvmcn-vm:64:1-2:2538


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