URIC ACID: HIS POSSIBLE ROLE AS ANTIOXIDANT IN HORSES WITH EQUINE INFECTIOUS ANEMIA
Abstract
Equine infectious anemia virus (EIAV) is a lentivirus, of the Retrovirus family, with an almost worldwide distribution, infecting equids (4). Uric acid may be a marker of oxidative stress (1) and may have a potential therapeutic role as an antioxidant On the other hand, like other strong reducing substances such as ascorbate, uric acid can also act as a peroxidant particularly at elevated levels. Thus, it is unclear whether elevated levels of uric acid in diseases associated with oxidative stress such as stroke and atherosclerosis are a protective response or a primary cause (5). For example, some researchers propose that hyperuricemia-induced oxidative stress is a cause of metabolic syndrome (5). On the other hand, plasma uric acid levels correlate with longevity in primates and other mammals (2). This is presumably a function of urate's antioxidant propertiesa) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
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