The Validation of Routine Analytical Methods in Histotechnology: A Practical Approach

Adrian I. ARDELEAN, Cornel CATOI


The present studies have the purpose to in house validation process in histotechnology for routine methods. The samples used were different types of tissue for quality control (QC) including positive and negative control. For calculation of the performance parameters has establish a grading scale for staining quality and an general quantification scale of the elements in slide samples. For proper internal control for quality assurance/ quality control (QA/QC) can be used: kidney, liver, skin and small intestine tissue and specific positive control and negative tissue control, when it is applicable. Regularly using of these samples and monitoring of theirs characteristics through control chart can assure the QA/QC and fitness to purpose of the methods.

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