Haematological and Biochemical Investigations in Rats with Rheumatoid Arthritis Induced by Freund Complete Adjuvant and Treated with Bee Venom

Nicodim FIŢ, Flore CHIRILĂ, Sorin RĂPUNTEAN, George NADĂŞ, Luciana PREOTEASA, Florin CUMPĂNAŞU

Abstract


In this paper we aimed to evaluate biochemical and hematological constants in rats with experimentally induced rheumatoid arthritis with Freund Adjuvant Complete undergoing bee venom therapy. The experiment was conducted on three groups of Wistar rats, which were divided in a group treated with Freund Adjuvant Complete, a group inoculated with complete Freund adjuvant and treated with bee venom and a control group. Experimental protocol was carried out by inducing arthritis with Freund adjuvant followed by a double administration every 48 hours of bee venom. Haematological values in groups treated with venom revealed a decrease in white blood cell count up to half baseline, a decrease in the number of erythrocytes, an increase in the total volume of platelets with a slight decrease in average platelets volume. There was an increase in granulocytes up to twice the original amount. Following the interpretation of biochemical results we found an increase in potassium and low levels of glucose in rats treated with venom.

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DOI: http://dx.doi.org/10.15835/buasvmcn-vm:1:68:6757


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