Novel Methods for Liposome Formulation: Advancements and Innovations
Liposomes are nanoscale spheroidal vesicles, predominantly composed of phospholipids, that offer a hydrophilic core surrounded by a hydrophobic bilayer. Their unique structure endows them with excellent biocompatibility and the ability to house both hydrophilic and lipophilic agents, making them exceptionally suited for targeted delivery applications. This versatility has seen liposomes gain widespread use in various industries, including medicine, pharmaceuticals, and nutraceuticals. This comprehensive review meticulously examines the spectrum of liposome fabrication techniques, providing insight into their respective advantages and limitations. Specifically, we scrutinize methods such as reverse phase evaporation, freeze drying, the Bangham method (also known as the thin film hydration technique), ethanol injection, the emulsion method, and ultrasonication. Each of these methodologies contributes to the array of liposomal forms, influencing their final characteristics and suitability for different applications. The present review categorizes liposomes based on the fabrication technique, offering a comparative perspective that is instrumental for researchers and practitioners in selecting the optimal method for their specific delivery system needs.
a) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).