PROSTATE-SPECIFIC ANTIGEN (PSA), A BIOMARKER OF NEOPLASTIC PROSTATIC DISEASE

  • Raluca Dumache Victor Babes’’ University of Medicine and Pharmacy, Department of Biochemistry, Eftimie Murgu Plaza ,no.2,Timisoara 300041,Romania;
  • Marilena Motoc
  • Daniela Ionescu ’ Victor Babes’’ University of Medicine and Pharmacy ,Department of Toxicology, Eftimie Murgu Plaza, no.2, Timisoara 300041
  • B Bumbăcilă ’ Victor Babes’’ University of Medicine and Pharmacy ,Department of Toxicology, Eftimie Murgu Plaza, no.2, Timisoara 300041
  • Maria Puiu ’Victor Babes’’ University of Medicine and Pharmacy, Department of Medical Genetics, Eftimie Murgu Plaza, no.2, Timisoara, 300041
DOI: https://doi.org/10.15835/buasvmcn-vm:65:1:1240
Keywords: prostate cancer ( PCa), benign prostatic hyperplasia ( BPH), prostate-specific antigen ( PSA), LUTS ( lower urinary tract symptoms).

Abstract

Prostate- specific antigen ( PSA) is a 33 KDa serine protease produced by both normal and neoplastic prostate epithelial cells. The use of PSA as serum biomarker greatly increased the chance to detect prostate cancer at an early and still curable stage . In our study, we want to show that there is a correlation between: patients’ age ( > 50 years old), PSA levels, and the increased incidence of prostate cancer . For our study, we enrolled 253 patients, age 50 to 80 years old, serum PSA levels > 4ng/ml, and no lower urinary tract symptoms. From the 253 patients, 168 patients were age 60 to 80 years old ( lot A) and 85 patients were age 50 to 60 years old ( lot B). From lot A 24 patients (14,28%) had serum PSA levels > 4ng/ml and 18 of them ( 10,71%) were diagnosed histologically with adenocarcinoma of the prostate . In lot B, 4 patients had serum PSA level> 4ng/ml and only one was diagnosed with adenocarcinoma of the prostate. The incidence of prostate cancer was higher in lot A (10,7%) in comparison with patients 50 to 60 years old ( 1,17%). The predictive value of PSA in the diagnosis of prostate cancer is 25 % for patients age 60 to 80 years old.
Published
2008-11-21
Issue
Vol. 65 No. 1 (2008)
Section
Research Articles
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