Biocompatibility Study Concerning Hematological Reactions Accompanying Subcutaneous Implantation of Some Dental Products in
Abstract
The experiment aims to evaluate, by a hematological point of view, the consequences (biocompatibility) of subcutaneous implantation of some dental composites (Ivoclar, Noritake, Vita, Vitadur) special prepared for this purpose, on blood cells (RBC, WBC and PLT). The experiment was conducted on 45 healthy Wistar adult rats, randomly and equally distributed in 9 groups of 5 animals per group. The implantation of dental composites was made subcutaneously, in the dorso-thoracic region of the rats. Subsequently, the rats were observed during the experiment (10 weeks) for any clinical (local or general), pathological and hematological reactions. The results obtained did not show any clinical or pathological effects, neither locally or even less systemic. As for hematological parameters investigated, the values obtained in experimental groups comparatively with the reference one did not show, with a very few exceptions, statistically significant differences, which indicate a possible pathogen effect of the studied dental composites on the bone marrow hematopoietic centers, or on the cellular components of blood, whether it’s red, white blood cells or platelets.
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