Biocompatibility Study Concerning Serum Biochemical Changes that Accompany Subcutaneous Implantation of Some Dental Materials in Wistar Rats
Abstract
The experiment is a biocompatibility study performed on Wistar rats. The goal of this experiment was to evaluate the physiological and pathological effects of some human dental materials implanted subcutaneous in Wistar rats. Were measured the serum levels of some biochemical constituents, such as enzymes (ASAT, ALAT, PAL, GGT), proteins (total serum proteins, albumins, globulins and A/G ratio) and minerals (Ca2+, Mg2+), which could provide some information on the tissues responses to implantation of these dental composites (Ivoclar, Noritake, Vita, Vitadur). The experiment was performed on 45 healthy Wistar adult rats, females, randomly and equally distributed in 9 groups, each of them containing five animals. The dental materials were implanted subcutaneously in the dorsal region of the rat’s thorax. Subsequently, the animals were observed during the whole period of the experiment (10 weeks), from the clinical (local or general), pathological and serum biochemical changes point of view. The clinical evaluation didn’t show any harmful effects on the animals. Concerning the biochemical parameters investigated, the variations recorded in the inoculated animals groups comparatively with the reference group didn’t show, except some isolated cases, significant statistically differences, which could suggest a pathogen effect of the studied materials.
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